The Mangosteen Pericarp, which is the rind or peel, contains the highest level of xanthones. The pulp, which is the fruit, known for being one of the tastiest fruits in the world. The seeds found in the pulp. Mangosteen has compounds that have antioxidant, anti-bacterial, anti-fungal, and anti-tumor activity. Laboratory tests have indicated that extracts of mangosteen have activity against several cancer cell lines including breast, liver, and leukemia. Mangosteen also contains anti-histamine and anti-inflammatory properties. Mangosteen has been used for many years as a medicinal treatment for diarrhea, skin infection and wounds in South Asia.

The latest in scientific research shows mangosteen contains a class of naturally occurring polyphenolic compound known as xanthones. Xanthones provide beneficial effects on cardiovascular diseases, including ischemic heart disease, atherosclerosis, hypertension, and thrombosis. Mangosteen shows vasorelaxant properties. Mycobacterium tuberculosis, Staphylococcus aureus, Mangosteen has shown inhibitory action against these organisms. Mangosteen is highly effective in weak immune system. There are several compounds found in the Mangosteen that appear to make this fruit so active as a nutritional component for the body.

Xanthones are broken down even further into mangostin, mangostenol, mangostenone A, Mangostenone B, trapezifolixanthone, tovophyllin B, alpha- and beta-mangostins, garcinone B, mangostinone, mangostanol and the flavonoid epicatechin. A study of the antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana on SKBR3 human breast cancer cell line, showed SKBR3 cells were cultured in the presence of mangosteen extract at various concentrations. Mangosteen showed a dose dependent inhibition of cell proliferation. We found that an antiproliferative effect of mangosteen was associated with apoptosis on breast cancer cell line by determinations of morphological changes and oligonucleosomal DNA fragments. Mangosteen also was found to inhibit ROS production. These investigations suggest that the mangosteen had strong anti-proliferation, potent anti-oxidation and induction of apoptosis. Mangosteen has potential for cancer chemoprevention, which is dose dependent as well as exposure time dependent. The ethanol extract of Mangosteen showed potent inhibitory activity against HIV-1 protease. The activity-guided purification of the extract resulted in the isolation of two active known compounds. The chemical structures of the isolated compounds were established by spectroscopic analysis as mangostin and gamma-mangostin.

Potential Benefits of Mangosteen
• Anti-viral
• Anti-bacterial
• Free radical fighter
• Cardio support
• Immune system Enhancer
• Powerful antioxidant
• Skin rashes, infections and wounds
• Diarrhea
• Anti-inflammatory
• Vasorelaxant

Mangosteen RX contains:

100% Pure Xanthones Rich Mangosteen Pericarp (hull powder) - No Fillers, No Additives, No Preservatives, No Artificial Colors. Gelatin capsule.

References and Studies:

Tapiero, H., et. al. “Polyphenols: do they play a role in the prevention of human pathologies?” Biomedicine & Pharmacotheraphy; 2002, 56 (4):200-207

Huang, D., et. al. “High-throughout assay of oxygen radical absorbency capacity using multichannel liquid handling system coupled with a microplate florescence reader in 96 we format.” Journal of Agricultural and Food Chemistry: 2002 50 (16): 4437-4444

Mangosteen in the Columbia Encyclopedia, 6 th edition, Columbia University Press 2003

Parkinson. R. “Mangoes, Lychees and Mangosteen.: Chinese Cuisine 2004

Nakatani, K. , et. al. “gamma-Mangostin inhibits IkappaB Kinase Activity with and decreases Lipopolysaccaride-induced cyclooxgenanase-2 Gene Expression in C6 Rat glioma Cells.” Molecular Pharmacology; June 24, 2004

Jiang, D.J. e. al. “ Pharmacological effects of xanthones as cardiovascular protective agents.” Cardiovascular Drug Reviews , 2004, 22(2):91-102

Biochem Pharmacol, 2002 Jan 1;63(1):73-9

Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives – J. Nat Prod 1997 May; 60 (5):519-24

Active constituents against HIV-1 protease from Mangosteen- Planta Med 1996 Aug;62(4):381-2

Mangostin inhibits the oxidative modification of human low density lipoprotein- Free radic Res. 1995 Aug.:23(2):175-84

Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana on SKBR3 human breast cancer cell line J.Ethnopharmacol, 2004 Jan:90(1):161-6

Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines

J.Nat Prod. 2003 Aug;55(8):1124-7

These statements have not been evaluated by the Food and Drug Administration. This information and product is not intended to diagnose treat, cure or prevent any disease. It is provided for educational purposes only and is not intended as medical advice. If you have any concerns you should consult with an appropriate health professional.